Int J Cancer 2007;120:2208-13. Ann N Y Acad Sci 1999;889:204-13. Sulforaphane has been shown in vitro studies to have anticancer effects against(1) Ambrosone CB, McCann SE, Freudenheim JL, et al. Side Effects of Broccoli Extract Broccoli and broccoli extract are safe to eat for healthy adults. In general, broccoli is safe to eat, and any side effects are not serious.,,, Br J Dermatol 2003;148:172-3. Int J Obes Relat Metab Disord 1998;22:227-9. The information contained in the post is for general purpose only and shouldn’t be considered as medical advice or as an alternative to medical advice. This is because too much intake of dietary fibers in our stomach can give rise to problems like malabsorption, intestinal gas, intestinal blockage, constipation, diarrhea, etc. Kim DJ, Han BS, Ahn B, et al. Although broccoli is good for regulating high blood pressure, it is advisable to eat them in moderation. This is because excessive consumption of broccoli can reduce the blood sugar to a dangerously low level, and this may give rise to hypoglycemia. Suggested Read- 33 Major Health & Beauty Benefits of Broccoli. All rights reserved. Broccoli sprout extract is POSSIBLY SAFE to take by mouth for up to 7 days. Broccoli might increase how quickly the liver breaks down some medications. Although dietary fibers are good for our stomach, it is advisable to eat broccoli in moderation. Bailey GS, Dashwood RH, Fong AT, et al. Allergic contact dermatitis to broccoli. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats. Bell MC, Crowley-Nowick P, Bradlow HL, et al. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This provides relief from constipation and also aids in treating various digestive problems like indigestion, irritable bowel syndrome, flatulence, abdominal pain, etc. View abstract. Natl Inst Health, Natl Inst Environmental Health Sci. IARC Sci Publ 1991;105:275-80. (2) Too Much Dietary Fiber is bad for our stomach. Biochem J 2002;364:301-7.. View abstract. Broccoli is a green vegetable which belongs to the cabbage family and is mainly grown for its flowering head. We currently have no information for BROCCOLI Interactions. Michnovicz JJ. Wu QJ, Yang Y, Vogtmann E, et al. they provide a number of health and beauty benefits. Altern.Med Rev 2000;5(5):455-462. J Nutr 2004;134:1134-8. P.S- Consider sharing this post, if you find it useful and/or interesting. that provides a number of health and beauty benefits. View abstract. Consuming broccoli on a regular and moderate basis has been found to be very beneficial for diabetic patients or those who are at the risk of developing diabetes. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Grubbs CJ, Steele VE, Casebolt T, et al. View abstract. Lampe JW, Peterson S. Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? Some of the less serious side effects of broccoli are: Since, it contains a high amount of fiber, it may cause gas. This is because the high level of potassium in our system can lower our blood pressure to a dangerously low level and may give rise to hypotension. The folate in broccoli protects newborn babies from neurological tube defects like spina bifida. Downsides of broccoli sprouts Side effects from eating broccoli sprouts or other sulforaphane-rich vegetables are so rare that the medical community considers them to have no substantial side effects. italica, Brocoli, Brócoli, Broccoli Flower, Calabrese, Purple Sprouting Broccoli. Broccoli Side Effects There are no such serious broccoli side effects. It is an excellent source of Consuming high-fiber broccoli sprouts may irritate your digestive tract, causing gassiness, the American Cancer Society reports 2 4. Also, if you are taking a lot of dietary fibers and not drinking plenty of water, then this can give rise to dehydration. View abstract. Zhao H, Lin J, Grossman HB, et al. View abstract. View abstract. Kristal AR, Lampe JW. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Walters DG, Young PJ, Agus C, et al. View abstract. View abstract. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. View abstract. Indole-3-carbinol for cancer prevention. Exon JH, South EH. Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables? View abstract. View abstract. 1- It should be kept unwashed in a plastic bag, taking care to remove as much air as possible. In this article, we will know about the major side effects of eating too many Broccolis, but first, let’s take a look at the below-mentioned nutrition chart of broccoli. Although broccoli is good food to be eaten during pregnancy, it is advisable to eat it in moderation. italica). (6) Eating Broccoli During Pregnancy And Nursing Period. Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer. Broccoli is a good source of many nutrients like vitamins, minerals, antioxidants, phytonutrients, etc. Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats. Saha S, Hollands W, Teucher B, et al. J Toxicol Environ Health A 2000;59:271-9. View abstract. (4) May Increase The Risk of Hypoglycemia. Also, if you are suffering from high blood pressure, and already taking medication for the same, then also you should eat broccoli in moderation as too much potassium in our system can interfere with the medication. View abstract. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. It may cause mild gastrointestinal upset, gas and bloating. (check all that apply), What factors are most important to you? Side Effects None reported. Brooks JD, Paton V. Potent induction of carcinogen defense enzymes with sulforaphane, a putative prostate cancer chemopreventive agent. Those who are taking blood-thinning medications should be careful while taking broccoli as it is packed with Vitamin K, which interferes with medications. (1) Too Many Antioxidants Are Bad For Our Health, (2) Too Much Dietary Fiber is bad for our stomach, (3) Might Be Allergic To Some Individuals, (4) May Increase The Risk of Hypoglycemia, (6) Eating Broccoli During Pregnancy And Nursing Period, 33 Major Health & Beauty Benefits of Broccoli, 6 Major Side Effects of Eating Too Many Turnips. Conaway CC, Getahun SM, Liebes LL, et al. Yu L, Gao B, Li Y, Wang TTY, Luo Y, Wang J, Yu LL. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Stram DO, Hankin JH, Wilkens LR, et al. Reduction of cancer risk by consumption of selenium-enriched plants: enrichment of broccoli with selenium increases the anticarcinogenic properties of broccoli. Bradlow HL, Michnovicz J, Telang NT, Osborne MP. View abstract. Chu YF, Sun J, Wu X, Liu RH. Jin L, Qi M, Chen DZ, et al. Also, if you are allergic to cruciferous vegetables like cauliflower, turnip, cabbage, etc., then you are also likely to be allergic to broccoli. View abstract. Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells. View abstract. View abstract. Hakooz, N. and Hamdan, I. Broccoli has many antioxidants, such as vitamin C, vitamin E, beta-carotene, and fiber, which can This is because over intake of antioxidants for a long period of time can cause more harm than the good. It is better to avoid it if somebody has hypothyroidism. Learn how to get more in your diet and potential side effects. Side effects of eating properly grown broccoli sprouts have not been reported. There isn't enough information to know if it is safe to use broccoli sprout extract for longer periods of time. Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. \"But the health benefits outweigh the discomfort.\" According to The Ohio State University Wexner Medical Center, people taking blood-thinning medications should watch their broccoli intake, since the vegetable's vitamin K content may interfere with the medication's effectiv… Excessive consumption of broccoli causes gastric issues and intestinal irritation. Health Benefits Of Broccoli – The Best Nutritional Advantages: The health effects of broccoli have been proven by many studies. Eur J Nutr. Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan. Broccoli might increase how quickly the liver breaks down some medications. Although it is rare and more research … Carcinogenesis 2003;24:497-503.. View abstract. AIDS Patient Care STDS 2003;17:609. also play a significant role in maintaining a healthy pregnancy. Brassica Oleracea Italica Group, Brassica oleracea var. As a nutritional therapist I try to practice what I preach, and aim to eat a wide variety of vegetables in my diet. WebMD does not provide medical advice, diagnosis or treatment. If you’ve been following PCF and reading about prostate cancer for a while, you have probably heard that broccoli is good for your prostate. Hypotension or low blood pressure is a condition in which our blood pressure drops to a very low level, and give rise to symptoms like fatigue, lightheadedness, dizziness, nausea, depression, clammy skin, etc. (check all that apply). View abstract. J Agric Food Chem 2002;50:7386-91. Finley JW. Side Effects of Eating Too Many Broccoli. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Rarely does something truly throw me for a loop, but I did put my fork down for a few moments after I opened up a journal, only to find a case report entitled “The Dangers of Broccoli.” First a little background: a Roux-en-y gastric bypass surgery is when you cut out 90% of the stomach. It has no side effects unless someone is allergic to broccoli. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Therefore, the broccoli is generally safe and the side effects are not dangerous. 2014;66(1):128-39. J Natl Cancer Inst 1986;77:269-76. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Srivastava adds, “There are also some other side effects of broccoli. Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice. The antioxidant responsive element (ARE) may explain the protective effects of cruciferous vegetables on cancer. J Natl Cancer Inst 1990;82:947-9. Inhibition of proliferation and modulation of estradiol metabolism: novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol. Glycemic index of broccoli is 15 which is considered as low, and this means broccoli reduces the rate at which sugar gets absorbed into the bloodstream, and prevents a sudden spike in the blood sugar level and thus helps in managing diabetes. Cancer Epidemiol Biomarkers Prev 2003;12:1403-9. This benefit of broccoli is mainly due to the presence of “Potassium” in it. Mithen R, Faulkner K, Magrath R, et al. Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis. Curr Drug Metab 2007;8(1):9-15. View abstract. View abstract. Prostate Cancer Prostatic Dis 2014;17(2):180-6. At this time there is not enough scientific information to determine an appropriate range of doses for broccoli. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . View abstract. Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or … Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol. Chakrabarti A, Prais L, Foulds IS. Anon. View abstract. View abstract. Food Chem Toxicol 2000;38:15-23. If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Broccoli medicine then it may not be safe to drive a vehicle or operate heavy machinery. The appropriate dose of broccoli depends on several factors such as the user's age, health, and several other conditions. Eating broccoli on a regular basis is very beneficial for our stomach and helps in keeping our digestive system healthy. Heiss E, Herhaus C, Klimo K, et al. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. Nutr Rev 2003;61:250-4. Ekiz F, Yuksel I, Kertmen N, Yuksel O. Liver toxicity due to broccoli juice. 2018;9(1):585-593. Potassium is a vital mineral that acts as a natural vasodilator, relaxes our blood vessels, and thus helps in regulating blood pressure. View abstract. This information may not fit your specific health circumstances. According to the University Diabetes Centre in Sweden, it can be offered as a broccoli drink or “shake.” It can be another Rosen CA, Woodson GE, Thompson JW, et al. If the broccoli consumed in large amount then their gas issue can occur as due to its high containing fiber. Rangkadilok N, Tomkins B, Nicolas ME, et al. J Biol Chem 2001;276:32008-15. 2012;56(12):1906-16. Prostate Cancer Prostatic Dis 1999;2:S8.. View abstract. Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Being a good source of many nutrients like vitamins and minerals etc. Taking broccoli along with some medications that are changed by the liver might decrease the effects and side effects of some medications. Giovannucci E, Rimm EB, Liu Y, et al. Hypoglycemia is a condition in which our blood sugar drops to a very low level, and is characterized by the symptoms like blurry vision, rapid heartbeat, pale skin, fatigue, dizziness, excessive hunger, excessive thirst, etc. View abstract. Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer--the U.K. NCRN Pomi-T study. View abstract. View abstract. Broccoli is a good source of many nutrients like vitamins, minerals, antioxidants, phytonutrients, etc. Before taking broccoli as a medicine, talk to your healthcare provider if you take any medications that are changed by the liver. Other nutrients like vitamins and minerals etc. View abstract. (3) Might Be Allergic To Some Individuals. Carcinogenesis 2004;25:1659-69. Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans. View abstract. Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies. Sulforaphane is the ingredient that is responsible for lowering blood sugar and it has little to no side effects. via Broccoli Nutrition, Benefits, Recipes, Side Once inside sulforaphane can damage important intracellular structures like mitochondria and enzymes. Gynecol Oncol 2000;78:123-9. Finley JW. \"All cruciferous vegetables can make you gassy,\" Jarzabkowski said. Nutr Rev 1998;56:127-30. Sulforaphane: Benefits, Side Effects, and Food Sources Written by Daisy Coyle, APD Sulforaphane is a natural plant compound found in many cruciferous vegetables like broccoli. Yuan F, Chen DZ, Liu K, et al. Taking broccoli along with some medications that are changed by the liver might decrease the effects and side effects of some medications. View abstract. View abstract. J Agric Food Chem 2002;50:6910-6. Broccoli may have anti-inflammatory effects, according to a 2014 study. Eating broccoli on a regular and moderate basis has been found to be very beneficial for providing relief from hypertension or high blood pressure, which is a leading cause of various cardiovascular problems like heart attack, heart stroke, irregular heartbeat, etc. Zhang Y, Callaway EC. Tse G, Eslick GD. View abstract. and the presence of … Srivastava B, Shukla Y. Antitumour promoting activity of indole-3-carbinol in mouse skin carcinogenesis. This side effect of antioxidants is because of the fact that in excessive quantity, antioxidants not only target the cancer cells but also the healthy cells around them and thus increase the risk of several types of cancers.